With the news of Spiller's injury, Bills fans should feel comfortable with Jackson leading the way in the backfield for as long as Spiller is out. After all, the veteran has three seasons with at least 900 rushing yards since 2009.
The 32-year-old is only two years removed from his last big season, but he could be called upon to get back to his old form.
Jackson had 97 yards and a score on 25 carries and nine receptions for 76 yards this season entering his matchup with the New York Jets. Against New York, he had 72 yards on seven attempts with four catches for 37 yards.
Spiller and Jackson have split carries throughout the season, and Jackson has taken advantage of his opportunities. He may not be the runner he once was, but he can still move the football.
Buffalo has the benefit of having two solid running backs. Jackson will reward all fantasy owners who take a chance on him. If Spiller misses any games, Jackson has the potential to rush for 100 yards and a score whenever he gets 15 or more carries.